Tg(COL4A3,Col4A4)1Lahe
Transgene Detail

Summary

• Symbol: Tg(COL4A3,Col4A4)1Lahe
• Name: transgene insertion 1, Laurence Heidet
• MGI ID: MGI:6470738
• Synonyms: COL4A3/COL4A4 Tg
• Transgene: Tg(COL4A3,Col4A4)1Lahe Location: unknown
• Alliance: Tg(COL4A3,Col4A4)1Lahe page

Transgene origin

• Strain of Origin: CBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(COL4A3,Col4A4)1Lahe expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  COL4A3 (1285)

  Col4a3

  (MGI:104688)

  human

  COL4A4 (1286)

  Col4a4

  (MGI:104687)

• Mutation details: The transgene was made by modifying YAC clone 870_B6 containing the cDNA of human COL4A3 and Col4A4. Line 1 was generated. (J:109362)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:109362 Heidet L, et al., A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice. Am J Pathol. 2003 Oct;163(4):1633-44
• All: 1 reference(s)