Tg(Prnp-Tardbp,-EGFP)19Zxu
Transgene Detail

Summary

• Symbol: Tg(Prnp-Tardbp,-EGFP)19Zxu
• Name: transgene insertion 19, Zuoshang Xu
• MGI ID: MGI:6469530
• Synonyms: PrP-TDP43-IRES-EGFP, TDP-43
• Transgene: Tg(Prnp-Tardbp,-EGFP)19Zxu Location: unknown
• Alliance: Tg(Prnp-Tardbp,-EGFP)19Zxu page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A loxP site, mouse Tardbp DNA binding protein cDNA sequence, an internal ribosome entry site (IRES), an enhanced green fluorescent protein sequence (EGFP), a second loxP site and polyA sequence was inserted between exon 2 and exon 3 of mouse Prnp gene. Founder line 19 was identified with GFP expression in central nervous system and desirable Tardbp expression level/pattern. (J:319624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:319624 Yang C, et al., Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice. PLoS One. 2022;17(2):e0255710
• All: 1 reference(s)