Tg(Myh6/tetO-Thbs1)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Thbs1)1Jmol
• Name: transgene insertion 1, Jeffery Molkentin
• MGI ID: MGI:6258263
• Transgene: Tg(Myh6/tetO-Thbs1)1Jmol Location: unknown
• Alliance: Tg(Myh6/tetO-Thbs1)1Jmol page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-Thbs1)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Thbs1 (MGI:98737)

• Tg(Myh6/tetO-Thbs1)1Jmol expression driven by 2 genes
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh8 (MGI:1339712)
  Not Specified	tetO

• Mutation details: Full-length mouse Thbs1 cDNA was placed under the regulatory control of the mouse Myh6/tetO minimal promoter. (J:341523)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:341523 Vanhoutte D, et al., Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy. Nat Commun. 2021 Jun 24;12(1):3928
• All: 1 reference(s)