Tg(Myh6/tetO-Vcp*K524A)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Vcp*K524A)1Jmol
• Name: transgene insertion 1, Jeffery Molkentin
• MGI ID: MGI:6361080
• Synonyms: VCP^K524A
• Transgene: Tg(Myh6/tetO-Vcp*K524A)1Jmol Location: unknown
• Alliance: Tg(Myh6/tetO-Vcp*K524A)1Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: Lysine 524, within the D2 ATPase domain of the mouse VCP protein (nucleotide changes: a1570g and a1571c; aaa to gca), was modified to alanine and placed under the control of the bigenic mouse Myh6 and tetO promoters. (J:279040)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:279040 Brody MJ, et al., Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis. J Biol Chem. 2019 May 31;294(22):8918-8929
• All: 1 reference(s)