Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber
Transgene Detail

Summary

• Symbol: Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber
• Name: transgene insertion 3798, Silke Nuber
• MGI ID: MGI:6281748
• Synonyms: 3KL, Thy1-3K alpha S
• Transgene: Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber Location: unknown
• Alliance: Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  mutated human gene

• Mutation details: The transgene contains a Thy1 promoter sequence directing expression of a modified human alpha synuclein cDNA carrying the E35K, E46K and E61K mutations. Founder line 3798 with low overexpression was subsequently established. (J:268903)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:268903 Nuber S, et al., Abrogating Native alpha-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 Oct 10;100(1):75-90.e5
• All: 3 reference(s)