Tg(tetO-CHMP2B*)3Fbga
Transgene Detail

Summary

• Symbol: Tg(tetO-CHMP2B*)3Fbga
• Name: transgene insertion 3, Fen-Biao Gao
• MGI ID: MGI:6278302
• Synonyms: CHMP2B^Intron5
• Transgene: Tg(tetO-CHMP2B*)3Fbga Location: unknown
• Alliance: Tg(tetO-CHMP2B*)3Fbga page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-CHMP2B*)3Fbga expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CHMP2B (25978)

  Chmp2b

  (MGI:1916192)

  Truncated at the carboxy terminus

• Mutation details: The human CHMP2B cDNA containing a missense mutation in the splice acceptor site of exon 6, a mutation identified in human familial FTD, is under the control of the tetracycline promoter. The mutation results in a truncation at the carboxy terminus such that the microtubule interacting and trafficking motif is lost. (J:227797)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:227797 Gascon E, et al., Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nat Med. 2014 Dec;20(12):1444-51
• All: 3 reference(s)