Tg(Cdkn1a*/tdTomato)260Rein
Transgene Detail

Summary

• Symbol: Tg(Cdkn1a*/tdTomato)260Rein
• Name: transgene insertion 260, H Christian Reinhardt
• MGI ID: MGI:6270403
• Synonyms: Cdkn1a^LSL.SUPER
• Transgene: Tg(Cdkn1a*/tdTomato)260Rein Location: unknown
• Alliance: Tg(Cdkn1a*/tdTomato)260Rein page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Cdkn1a*/tdTomato)260Rein expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cdkn1a (MGI:104556)

• Mutation details: BAC BMQ-448E21 carrying the genomic Cdkn1a mouse sequence was modified to replace the stop codon in exon 3 with a tdTomato reporter followed by polyA sequence. A loxP-STOP-loxP (LSL) cassette was inserted into intron 2. The transgene inserted on the centromeric region of chromosome 6. (J:266858)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:266858 Torgovnick A, et al., The Cdkn1a(SUPER) Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Rep. 2018 Oct 23;25(4):1027-1039.e6
• All: 1 reference(s)