Tg(Atoh1-Bmi1)T26Mro
Transgene Detail

Summary

• Symbol: Tg(Atoh1-Bmi1)T26Mro
• Name: transgene insertion T26, Silvia Marino
• MGI ID: MGI:6259667
• Synonyms: Math1-Bmi1
• Transgene: Tg(Atoh1-Bmi1)T26Mro Location: unknown
• Alliance: Tg(Atoh1-Bmi1)T26Mro page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Atoh1-Bmi1)T26Mro expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bmi1 (MGI:88174)

• Mutation details: This transgene comprises a 1,385-bp mouse genomic DNA fragment containing an enhancer sequence residing ~3 kb upstream of the coding sequence for atonal bHLH transcription factor 1 (Atoh1, also called Math1; GenBank: AF218258, nt 1-1385) followed by the human beta-globin basal promoter (nt -31 through +12) driving expression of the full-length, 3.1-kb mouse Bmi1 polycomb ring finger oncogene (Bmi1) cDNA. Two transgenic lines (of four generated), designated T25 and T26, overexpressed Bmi1 mRNA, as determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis, and BMI1 protein, as quantified by immunoblot analysis, in cerebellum; immunohistochemical labeling of cerebella of 6-day-old mice localized expression of BMI1 to the outer layer of the external granule cell layer, where proliferation of granule cell precursors occurs. (J:193730)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:193630 Fujimoto A, et al., GJB6, of which mutations underlie Clouston syndrome, is a potential direct target gene of p63. J Dermatol Sci. 2013 Feb;69(2):159-66
• All: 3 reference(s)