Tg(Scgb1a1-Il5)NJ.1726Nal
Transgene Detail

Summary

• Symbol: Tg(Scgb1a1-Il5)NJ.1726Nal
• Name: transgene insertion NJ.1726, Nancy A Lee
• MGI ID: MGI:6258571
• Transgene: Tg(Scgb1a1-Il5)NJ.1726Nal Location: unknown
• Alliance: Tg(Scgb1a1-Il5)NJ.1726Nal page

Transgene origin

• Strain of Origin: (CBA/CaJ X C57BL/6J)F1 x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Scgb1a1-Il5)NJ.1726Nal expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il5 (MGI:96557)	rat promoter, mouse cDNA/genomic gene

• Mutation details: The rat promoter drives the expression of the mouse gene in lung epithelium. The gene is constructed by fusing 170 bp 5' cDNA sequence to the remainder of the gene's genomic sequence (including ~1.2 kb 3' flanking sequence). Of the three founder lines - NJ.1659, NJ.1723, NJ.1726 - the latter was found to have the highest copy number and expression and severest pathology and was chosen for further study. (J:41589)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:41589 Lee JJ, et al., Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J Exp Med. 1997 Jun 16;185(12):2143-56
• All: 7 reference(s)