Tg(Myh6-Tnni3*P83S)270Ammu
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*P83S)270Ammu
• Name: transgene insertion 270, Anne Murphy
• MGI ID: MGI:6201695
• Synonyms: cTnIP82S
• Transgene: Tg(Myh6-Tnni3*P83S)270Ammu Location: unknown
• Alliance: Tg(Myh6-Tnni3*P83S)270Ammu page

Transgene origin

• Strain of Origin: C57BL/6 x A/J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Myh6-Tnni3*P83S)270Ammu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tnni3 (29248)

  Tnni3

  (MGI:98783)

  rat cDNA carrying a P82S substitution

• Mutation details: The transgene was designed with the mouse alpha myosin heavy chain (Myh6) promoter directing expression of a modified rat troponin I, cardiac 3 cDNA sequence followed by a human growth hormone (hGH) gene containing a polyA signal. The Tnni3 sequence contains a proline to serine substitution as residue 83 (P83S). This substitution mimics a known human sequence variant (P82S) found in 3% of normal African Americans. Founder line 270 was selected as the representative line. (J:265588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:265588 Ramirez-Correa GA, et al., Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts beta-adrenergic response, and impairs myofilament cooperativity. J Appl Physiol (1985). 2015 Jan 15;118(2):212-23
• All: 1 reference(s)