Tg(TREM2)1Xwy
Transgene Detail

Summary

• Symbol: Tg(TREM2)1Xwy
• Name: transgene insertion 1, X William Yang
• MGI ID: MGI:6194033
• Transgene: Tg(TREM2)1Xwy Location: unknown
• Alliance: Tg(TREM2)1Xwy page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TREM2)1Xwy expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TREM2 (54209)

  Trem2

  (MGI:1913150)

• Mutation details: The human bacterial artificial chromosome (BAC) RP11-237K15 containing the entire TREM2 gene with adjacent 50 kb + flanking regions, and the TREML1, TREML2, and TREML4 genes, was modified by deleting the TREML1, TREML2, and TREML4 genes. The modifications to the BAC were as follows: exons 1 through 3 and the proximal promoter region (most of the protein coding sequence) were deleted in TREML4; the proximal promoter region as well as exons 1, 2, 5 and 6 (80% of the protein coding sequence) were deleted in TREML1; and exons 2 and 3 of the TREML2 gene were deleted (resulting in a frameshift with early stop codon in exon 4). Founder line A, which carries 1 or 2 copies of the transgene (transgene copy number estimated by genomic qPCR) was subsequently established. (J:262250)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:262250 Lee CYD, et al., Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018 Mar 7;97(5):1032-1048.e5
• All: 1 reference(s)