Tg(RHD)1Goo
Transgene Detail

Summary

• Symbol: Tg(RHD)1Goo
• Name: transgene insertion 1, Dominique Goossens
• MGI ID: MGI:6148219
• Synonyms: RHD-BAC1, TG_RHD_BAC1
• Transgene: Tg(RHD)1Goo Location: unknown
• Alliance: Tg(RHD)1Goo page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RHD)1Goo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RHD (6007)

  Rhd	(MGI:1202882)

• Mutation details: A human BAC (BAC H0193H09 from the CEPH) carrying RHD gene was used to make transgenic mice. Transcripts from the human gene are detected, but no protein expression was detected with a panel of anti-RhD monoclonal antibodies recognizing different epitopes or a polyclonal anti-RhD. Human RhD protein is not expressed in mouse erythroid cells in the absence of human RHAG despite the presence of murine Rhag. In the presence of human RHAG, a low level of human RHD is detectable. (J:209676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:209676 Goossens D, et al., Mice expressing RHAG and RHD human blood group genes. PLoS One. 2013;8(11):e80460
• All: 1 reference(s)