Tg(Myh6/tetO-Mybpc3*)#Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Mybpc3*)#Rbns
• Name: transgene insertion, Jeffrey Robbins
• MGI ID: MGI:5909970
• Transgene: Tg(Myh6/tetO-Mybpc3*)#Rbns Location: unknown
• Alliance: Tg(Myh6/tetO-Mybpc3*)#Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-Mybpc3*)#Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Mybpc3	40-kDa N-terminal fragment

• Mutation details: This transgene contains a 40-kDa N-terminal fragment of Mybpc3 (amino acids 1-271, containing the C0 domain, a Pro/Ala-rich region, the C1 domain, and 17 residues of the M domain) under the transcriptional control of a mouse alpha-myosin heavy chain promoter fused to the tetracycline-response element (tetO). An N-terminal c-myc tag encoding the human c-myc peptide was inserted after the initiation methionine codon to differentiate transgenic protein from the endogenous one. Some leakage in the expression of the 40-kDa fragment is seen. Multiple lines were generated, however the pound (#) symbol is used because line number is not specified. (J:213370)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:213370 Razzaque MA, et al., An endogenously produced fragment of cardiac myosin-binding protein C is pathogenic and can lead to heart failure. Circ Res. 2013 Aug 16;113(5):553-61
• All: 2 reference(s)