Tg(Alb-Selp)9Rpmc
Transgene Detail

Summary

• Symbol: Tg(Alb-Selp)9Rpmc
• Name: transgene insertion 9, Rodger P McEver
• MGI ID: MGI:5908730
• Synonyms: Tg-sP-selectin
• Transgene: Tg(Alb-Selp)9Rpmc Location: unknown
• Alliance: Tg(Alb-Selp)9Rpmc page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-Selp)9Rpmc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Selp (MGI:98280)	fused to a C-terminal 8-residue epitope for the Ca2+ dependent mAb HPC4

• Mutation details: The transgenic construct contains cDNA encoding the entire extracellular domain of mouse Selp fused to a C-terminal 8-residue epitope for the Ca2+ dependent mAb HPC4, under the control of the mouse Alb, albumin, gene promoter, and a 3' bovine growth hormone poly(A) signal sequence. Founder mice stably express approximately 3.5 higher levels of the protein in plasma. (J:243484)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:243484 Panicker SR, et al., Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice. Blood. 2017 Jul 13;130(2):181-191
• All: 1 reference(s)