Tg(Myh6-Mybpc3*)24Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mybpc3*)24Rbns
• Name: transgene insertion 24, Jeffrey Robbins
• MGI ID: MGI:5908461
• Synonyms: MyBP-C.mut2
• Transgene: Tg(Myh6-Mybpc3*)24Rbns Location: unknown
• Alliance: Tg(Myh6-Mybpc3*)24Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Mybpc3*)24Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mybpc3 (MGI:102844)	truncation lacking the myosin binding domain

• Mutation details: The mouse cardiac truncated protein lacking the myosin protein binding domain (missing the 240 nucleotides at the 3' end) is under the control of the mouse alpha-myosin heavy chain promoter. The human myc epitope is placed after the initiator methionine residue. Western blot analysis indicates very little truncated protein in hearts while endogenous levels of Mybpc3 are unaffected. Multiple lines were established including 19, 24, and 133. All lines exhibit similar phenotypes and line 24 is entered as a representative line. (J:59702)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:59702 Yang Q, et al., In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy. Circ Res. 1999 Oct 29;85(9):841-7
• All: 1 reference(s)