Tg(Myh6-ACTC1*E361G)361.20Sbm
Transgene Detail

Summary

• Symbol: Tg(Myh6-ACTC1*E361G)361.20Sbm
• Name: transgene insertion 361.20, Steven B Marston
• MGI ID: MGI:5906238
• Synonyms: ACTC E361G
• Transgene: Tg(Myh6-ACTC1*E361G)361.20Sbm Location: unknown
• Alliance: Tg(Myh6-ACTC1*E361G)361.20Sbm page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ACTC1*E361G)361.20Sbm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACTC1 (70)

  Actc1

  (MGI:87905)

  this mutation results in a dominant-negative

• Mutation details: The heart restricted murine alpha-myosin heavy chain promoter drives the expression of human cardiac actin with a glycine substitution for glutamic acid at amino acid 361 (E361G). This is a dominant negative mutation. Two lines were established: 361.20 and 361.13. Mice express this mutation at around 50% of total actin in the heart. (J:242344)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:242344 Song W, et al., Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J Mol Cell Cardiol. 2010 Sep;49(3):380-9
• All: 3 reference(s)