Tg(CAG-GFP,-EIF4EBP1)2877Als
Transgene Detail

Summary

• Symbol: Tg(CAG-GFP,-EIF4EBP1)2877Als
• Name: transgene insertion 2877, Albert La Spada
• MGI ID: MGI:5896794
• Synonyms: Tg-4EBP1wt
• Transgene: Tg(CAG-GFP,-EIF4EBP1)2877Als Location: unknown
• Alliance: Tg(CAG-GFP,-EIF4EBP1)2877Als page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-GFP,-EIF4EBP1)2877Als expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EIF4EBP1 (1978)

  Eif4ebp1

  (MGI:103267)

• Mutation details: The transgene has (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (from CAGGS), a loxP-GFP-3xSTOP-loxP cassette and a cDNA sequence encoding human EIF4EBP1. In the absence of Cre recombinase, mice have widespread expression of GFP, and no human EIF4EBP1 expression. (J:238961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:238961 Tsai SY, et al., Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016 Aug 16;16(7):1903-14
• All: 2 reference(s)