Tg(Tcra,Tcrb)6482Dmky
Transgene Detail

Summary

• Symbol: Tg(Tcra,Tcrb)6482Dmky
• Name: transgene insertion 6482, David M Kemeny
• MGI ID: MGI:5816373
• Synonyms: BT-II
• Transgene: Tg(Tcra,Tcrb)6482Dmky Location: unknown
• Alliance: Tg(Tcra,Tcrb)6482Dmky page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra,Tcrb)6482Dmky expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Rearranged Blo t 5 peptide 55-70 (from the storage mite Blomia tropicalis) specific T cell ValphaJalpha and VbetaD&betaJbeta genes were cloned into pTalpha and pTbeta cassettes. Transgenic constructs generated from these cassette vectors, contain the alpha-chain and beta-chain of the T-cell receptor from a T cell hybridoma clone> (J:237613)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:237613 Chua YL, et al., Blomia tropicalis-Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13-Dependent Mechanism. J Immunol. 2016 Nov 15;197(10):3771-3781
• All: 1 reference(s)