Tg(Slc6a11-cre/ERT2)1Khakh
Transgene Detail
|
Symbol: |
Tg(Slc6a11-cre/ERT2)1Khakh |
Name: |
transgene insertion 1, Baljit Khakh |
MGI ID: |
MGI:5806574 |
Synonyms: |
GAT3-Cre/ERT2 BAC, Slc6a11-Cre/ERT2 BAC |
Transgene: |
Tg(Slc6a11-cre/ERT2)1Khakh Location: unknown
|
Alliance: |
Tg(Slc6a11-cre/ERT2)1Khakh page
|
|
|
Transgene Type: |
|
Transgenic (Inducible, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Tg(Slc6a11-cre/ERT2)1Khakh expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Slc6a11 (MGI:95630) |
|
|
|
|
Mutation details: The transgene contains the entire solute carrier family 6 (neurotransmitter transporter GABA) member 11 locus (Slc6a11 [GAT3 or Gabt4]), as well as ~48 kbp 5' (centromeric) flanking region and ~36 kbp 3' (telomeric) flanking region from BAC RP23-470B21. Using homologous recombination/BAC recombineering, a CreER cDNA sequence followed by an SV40 polyadenylation signal was inserted into exon 1 of the BAC Slc6a11 gene immediately preceding the translation initiation codon. No other loci on the BAC were altered. Unstated number of founder lines with germline transmission are generated. A founder line #1 was established and characterized.
(J:249928)
|
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
Slc6a11
(mouse)
|
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:249928 Srinivasan R, et al., New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron. 2016 Dec 21;92(6):1181-1195 |
All: |
1 reference(s) |
|