Tg(Thy1-MAPT*L266V*G272V)13Ema
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*L266V*G272V)13Ema
• Name: transgene insertion 13, Eliezer Masliah
• MGI ID: MGI:5774860
• Synonyms: 3R Tau
• Transgene: Tg(Thy1-MAPT*L266V*G272V)13Ema Location: unknown
• Alliance: Tg(Thy1-MAPT*L266V*G272V)13Ema page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*L266V*G272V)13Ema expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The human Tau containing three ~32 amino acid repeats bearing the L266V and G272V mutations associated with familial forms of Picks Disease is under the control of the neuronal mouse Thy1 promoter. Line 13 is a high expressing line and expresses 8 fold higher levels than line 2. (J:229181)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:229181 Rockenstein E, et al., A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. PLoS One. 2015;10(3):e0121570
• All: 3 reference(s)