Tg(Prnp/PRNP)1Drb
Transgene Detail

Summary

• Symbol: Tg(Prnp/PRNP)1Drb
• Name: transgene insertion 1, David R Brown
• MGI ID: MGI:5762584
• Synonyms: PrP Chicken-repeats, Tg(Prnp-chkhexrepeat)
• Transgene: Tg(Prnp/PRNP)1Drb Location: unknown
• Alliance: Tg(Prnp/PRNP)1Drb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp/PRNP)1Drb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  kudu	PRNP	ENA Sequence: X74771.1

• Mutation details: This transgene encodes a chimeric prion protein in which the N-terminal octameric repeat region of the mouse protein, comprising four tandem repeats of the amino acid sequence PHGGGWGQ, has been replaced by the analogous region from the chicken prion protein, which contains nine tandem copies of the hexapeptide sequence PHNPGY. Mice homozygous for the transgene and for a knockout allele of the endogenous Prnp gene express the chimeric protein at wild-type levels with correct membrane location and orientation. The substitution affects the metal-coordinating properties of the protein. (J:169366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169366 MouseBook^TM, Information obtained from MouseBook^TM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished. 2005-2013
• All: 1 reference(s)