Tg(Rr695562*-lacZ)mtFdz
Transgene Detail

Summary

• Symbol: Tg(Rr695562*-lacZ)mtFdz
• Name: transgene insertion mt, Anne Fernandez
• MGI ID: MGI:5648218
• Synonyms: 17:11mt, Tg(Rr646694*-lacZ)#Fdz
• Transgene: Tg(Rr695562*-lacZ)mtFdz Location: unknown
• Alliance: Tg(Rr695562*-lacZ)mtFdz page

Transgene origin

• Strain of Origin: C57BL/6 or CBA

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: Transgenic mice were generated that carry the minimal MyoD promoter Rr646694 (proximal regulatory region, PRR) with a mutated upstream Myod1 enhancer Rr695562 (distal regulatory region, DRR), where the CArG-box sequence was modified from CcATTTTATAG to CgATTTTATAG, driving expression of a beta-galactosidase gene (lacZ) in regenerating muscles. The mutation abolishes enhancer activity and thus reporter expression. Line numbers were not specified. (J:209201)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The transgene construct was microinjected into fertilized oocytes from "B6CBA mice." (J:209201)

References

• Original: J:209201 L'honore A, et al., MyoD distal regulatory region contains an SRF binding CArG element required for MyoD expression in skeletal myoblasts and during muscle regeneration. Mol Biol Cell. 2003 May;14(5):2151-62
• All: 1 reference(s)