Tg(Cnp-TVA,-lacZ)B8Ubc
Transgene Detail

Summary

• Symbol: Tg(Cnp-TVA,-lacZ)B8Ubc
• Name: transgene insertion B8, Uppsala University
• MGI ID: MGI:5648077
• Synonyms: Tg(Cnp-CD320,-lacZ)B8Ubc
• Transgene: Tg(Cnp-TVA,-lacZ)B8Ubc Location: unknown
• Alliance: Tg(Cnp-TVA,-lacZ)B8Ubc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct contained the entire mouse Cnp promoter region coupled to the 800-bp quail cDNA encoding the glycosylphosphatidylinositol-linked form of TVA (CD320 or Tv-a) gene, the receptor for avian retrovirus ALV, subgroup A (ALV-A), followed by an IRES (internal ribosomal entry site) sequence and the lacZ gene. Pronuclear injection generated three chimera founders with germ-line transmission (A7, B8 and C16). After initial characterization for expression of TVA the B8 line was selected for further breeding. (J:151346)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available

Notes

All were phenotypically normal, viable and fertile.

References

• Original: J:151346 Lindberg N, et al., Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene. 2009 Jun 11;28(23):2266-75
• All: 3 reference(s)