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Tg(Cnp-TVA,-lacZ)B8Ubc
Transgene Detail
Summary
Symbol: Tg(Cnp-TVA,-lacZ)B8Ubc
Name: transgene insertion B8, Uppsala University
MGI ID: MGI:5648077
Synonyms: Tg(Cnp-CD320,-lacZ)B8Ubc
Transgene: Tg(Cnp-TVA,-lacZ)B8Ubc  Location: unknown  
Alliance: Tg(Cnp-TVA,-lacZ)B8Ubc page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgenic construct contained the entire mouse Cnp promoter region coupled to the 800-bp quail cDNA encoding the glycosylphosphatidylinositol-linked form of TVA (CD320 or Tv-a) gene, the receptor for avian retrovirus ALV, subgroup A (ALV-A), followed by an IRES (internal ribosomal entry site) sequence and the lacZ gene. Pronuclear injection generated three chimera founders with germ-line transmission (A7, B8 and C16). After initial characterization for expression of TVA the B8 line was selected for further breeding. (J:151346)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Notes
All were phenotypically normal, viable and fertile.
References
Original:  J:151346 Lindberg N, et al., Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene. 2009 Jun 11;28(23):2266-75
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory