Tg(TG-KCNIP3*)7Cnbc
Transgene Detail

Summary

• Symbol: Tg(TG-KCNIP3*)7Cnbc
• Name: transgene insertion 7, Centro Nacional de Biotecnologia
• MGI ID: MGI:5646252
• Synonyms: LeuBTA7
• Transgene: Tg(TG-KCNIP3*)7Cnbc Location: unknown
• Alliance: Tg(TG-KCNIP3*)7Cnbc page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TG-KCNIP3*)7Cnbc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KCNIP3 (30818)

  Kcnip3

  (MGI:1929258)

• Mutation details: The cDNA encoding human KCNIP3 (DREAM) with two aminoacid substitutions at EFhands 2, 3 and 4 (EFmDREAM) was inserted downstream of the bovine Thyroglobulin promoter to direct expression in the thyroid gland. The amino acid substitutions rendered the mutant insensitive to Ca2+. (J:148712)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:148712 Rivas M, et al., The DREAM protein is associated with thyroid enlargement and nodular development. Mol Endocrinol. 2009 Jun;23(6):862-70
• All: 1 reference(s)