Tg(EEF1A1-SHC1)1Ravi
Transgene Detail

Summary

• Symbol: Tg(EEF1A1-SHC1)1Ravi
• Name: transgene insertion 1, Kodi S Ravichandran
• MGI ID: MGI:5613976
• Synonyms: ShcWT
• Transgene: Tg(EEF1A1-SHC1)1Ravi Location: unknown
• Alliance: Tg(EEF1A1-SHC1)1Ravi page

Transgene origin

• Strain of Origin: 129S

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(EEF1A1-SHC1)1Ravi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SHC1 (6464)

  Shc1	(MGI:98296)

• Mutation details: The transgenic construct contains a human eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) promoter/enhancer elements driving expression of a wildtype flag-tagged human src homology 2 domain-containing transforming protein C1 (SHC1) cDNA. The SHC1 sequence is fused to an internal ribosome entry site (IRES)-enhanced green fluorescent protein (EGFP) fusion protein, and is preceded by a loxP-flanked SV40 polyadenylation signal. (J:118108)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:118108 Trampont P, et al., ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development. Mol Cell Biol. 2006 Dec;26(23):9035-44
• All: 2 reference(s)