Tg(Scgb1a1-TFRC/OVA)1Adl
Transgene Detail

Summary

• Symbol: Tg(Scgb1a1-TFRC/OVA)1Adl
• Name: transgene insetion 1, Andrew D Luster
• MGI ID: MGI:5575977
• Synonyms: CC10-OVA
• Transgene: Tg(Scgb1a1-TFRC/OVA)1Adl Location: unknown
• Alliance: Tg(Scgb1a1-TFRC/OVA)1Adl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Scgb1a1-TFRC/OVA)1Adl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	OVAL (396058)

• Mutation details: The CC10-OVA transgene was designed with a 2.4 kbp promoter from rat Clara cell secretory protein (CC10 or Scgb1a1), a DNA sequence encoding the transmembrane domain (residues 2-118) of the human transferrin receptor (CD71 or TFRC) fused to a DNA sequence encoding amino acids 139-385 of mature chicken ovalbumin (the p139-387 segment including the p257-264 [SIINFEKL] and p323-339 epitopes recognized by OT-I and OT-II TCR transgenic cells, respectively). The founder mouse line with the highest copy number (at least three copies) was identified and used. (J:100652)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:100652 Medoff BD, et al., BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation. J Exp Med. 2005 Jul 4;202(1):97-110
• All: 1 reference(s)