Tg(Igh-ROR1)1Kip
Transgene Detail

Summary

• Symbol: Tg(Igh-ROR1)1Kip
• Name: transgene insertion 1, Thomas J Kipps
• MGI ID: MGI:5571366
• Synonyms: ROR1 Tg
• Transgene: Tg(Igh-ROR1)1Kip Location: unknown
• Alliance: Tg(Igh-ROR1)1Kip page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-ROR1)1Kip expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ROR1 (4919)

  Ror1	(MGI:1347520)

• Mutation details: The human ROR1 is under the control of the B cell specific murine Igh promoter/enhancer (containing the mouse V(H) promoter and Igh-mu-enhancer). One line was made. (J:206368)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:206368 Widhopf GF 2nd, et al., ROR1 can interact with TCL1 and enhance leukemogenesis in Emu-TCL1 transgenic mice. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):793-8
• All: 1 reference(s)