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Tg(Prnp-APPSweArc)#Rmni
Transgene Detail
Summary
Symbol: Tg(Prnp-APPSweArc)#Rmni
Name: transgene insertion, Roger M Nitsch
MGI ID: MGI:5553464
Synonyms: arcABeta
Transgene: Tg(Prnp-APPSweArc)#Rmni  Location: unknown  
Alliance: Tg(Prnp-APPSweArc)#Rmni page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-APPSweArc)#Rmni expresses 1 gene
 
Mutation detailsThe human APP695 containing the Swedish K670N and M671L and Artic E693G mutations is under the control of the prion protein promoter. The pound symbol (#) is used because the line is not specified, although the line used has a 6-fold overexpression of APP compared to endogenous APP levels. (J:128080)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:128080 Knobloch M, et al., Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging. 2007 Sep;28(9):1297-306
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory