Tg(Ubc-IglvAMS9,-IghvAMS9)16Nemz
Transgene Detail

Summary

• Symbol: Tg(Ubc-IglvAMS9,-IghvAMS9)16Nemz
• Name: transgene insertion 16, David Nemazee
• MGI ID: MGI:5516432
• Synonyms: Tg(Ubc-scFv)16Nemz
• Transgene: Tg(Ubc-IglvAMS9,-IghvAMS9)16Nemz Location: unknown
• Alliance: Tg(Ubc-IglvAMS9,-IghvAMS9)16Nemz page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ubc-IglvAMS9,-IghvAMS9)16Nemz expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igh (MGI:96442)
  mouse	Igl (MGI:96526)

• Mutation details: Variable lambda and variable heavy chain cDNAs derived from AMS9.1 hybridoma RNA were placed under the control of the ubiquitin C promoter. The transgene drives ubiquitous expression of a superantigen reactive to mouse IgD of the 'a' allotype. (J:159877)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:159877 Duong BH, et al., Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen. J Immunol. 2010 Apr 15;184(8):4143-58
• All: 1 reference(s)