Tg(Tagln-Pth1r*)2Towl
Transgene Detail

Summary

• Symbol: Tg(Tagln-Pth1r*)2Towl
• Name: transgene insertion 2, Dwight Towler
• MGI ID: MGI:5509011
• Transgene: Tg(Tagln-Pth1r*)2Towl Location: unknown
• Alliance: Tg(Tagln-Pth1r*)2Towl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tagln-Pth1r*)2Towl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pth1r (MGI:97801)

• Mutation details: The vascular smooth muscle cell-specific mouse Tagln (SM22) promoter was used to drive expression of a 1.8 kb cDNA encoding the open reading frame of the H223R constitutively active form of mouse Pthr1 upstream of rabbit beta-globin 3'UTR and polyA sequences. (J:175050)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:175050 Cheng SL, et al., Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res. 2010 Jul 23;107(2):271-82
• All: 1 reference(s)