Tg(LRRK2*R1441G)3IMjff
Transgene Detail

Summary

• Symbol: Tg(LRRK2*R1441G)3IMjff
• Name: transgene insertion 3I, The Michael J Fox Foundation
• MGI ID: MGI:5466850
• Synonyms: Tg(LRRK2*R1441G)3IGrsr
• Transgene: Tg(LRRK2*R1441G)3IMjff Location: Chr1:121883729-121923584 bp Genetic Position: Chr1, Syntenic
• Alliance: Tg(LRRK2*R1441G)3IMjff page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intergenic deletion, Nucleotide substitutions
• Tg(LRRK2*R1441G)3IMjff expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: A human bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a 188 kb BAC containing the entire human LRRK2 (leucine-rich repeat kinase 2) gene with 29 kb upstream of the LRRK2 start codon and 42 kb downstream of the LRRK2 stop codon. Bioinformatics analysis predicted that no other genes are present in the BAC. This BAC was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2 R1441G (4321 C>G) mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. Transgene insertion occurred on Chr 1, causing a 39,855 bp deletion. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 3 reference(s)