Sum5 Gene Detail

Summary

• Symbol
  Sum5
• Name
  suppressor of methyl CpG binding protein 2, 5

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:5489928
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 18, Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (ENU)
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice heterozygous for the mutation exhibit improved Rett syndrome phenotypes.

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:198551 Buchovecky CM, et al., A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett Syndrome. Nat Genet. 2013;45(9):1013-20
• Latest
  J:323637 Enikanolaiye A, et al., Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology. Genome Res. 2020 Apr;30(4):540-552