Mirc33 Complex/Cluster/Region Detail

Summary

• Symbol
  Mirc33
• Name
  microRNA cluster 33, including Mir29a through Mir29b-1

• Feature Type
  complex/cluster/region
• IDs
  MGI:5451075
• Cluster Members
  Mir29a, Mir29b-1 (2 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 6, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  62 phenotypes from 4 alleles in 3 genetic backgrounds
  9 phenotypes from multigenic genotypes
  25 phenotype references
  

• All Mutations and Alleles
  7
• Endonuclease-mediated
  2
• Targeted
  5
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-out allele exhibit premature thymic involution. Mice homozygous for another knock-out allele exhibit increased Th1 differentiation, lymphoid hypoplasia and decreased susceptibility to EAE.

Other Database
Links

miRBase

MI0000143, MI0000576

References

• Summaries
  All 29

  Phenotypes 25
• Earliest
  J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
• Latest
  J:368317 Czopik AK, et al., HIF-2alpha-dependent induction of miR-29a restrains T(H)1 activity during T cell dependent colitis. Nat Commun. 2024 Sep 14;15(1):8042

Mirc33 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir29a, microRNA 29a	miRNA gene	Chr6:31039595-31039682 (-)
Mir29b-1, microRNA 29b-1	miRNA gene	Chr6:31039958-31040028 (-)