Tg(CMV-Mapkapk5*L337A)AUlm
Transgene Detail

Summary

• Symbol: Tg(CMV-Mapkapk5*L337A)AUlm
• Name: transgene insertion A, Ugo Moens
• MGI ID: MGI:5432234
• Synonyms: line A, MK5L337A, MK5_L337A line A
• Transgene: Tg(CMV-Mapkapk5*L337A)AUlm Location: unknown
• Alliance: Tg(CMV-Mapkapk5*L337A)AUlm page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene comprises the human cytomegalovirus (CMV) immediate early gene promoter followed by an SV40 intron, a cDNA encoding N-terminally hemagglutinin- (HA-) tagged mouse MAP kinase-activated protein kinase 5 (MAPKAPK5) in which leucine at amino acid position 337 has been replaced by alanine (L337A), and an SV40 polyadenylation signal. The L337A amino acid substitution confers constitutive activity on the kinase. Expression of the transgene was confirmed by northern blot analysis of RNA isolated from heart tissue. (J:186303)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:186303 Gerits N, et al., Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity. Behav Brain Funct. 2007;3:58
• All: 1 reference(s)