Tg(Prnp*)8015Sbp
Transgene Detail

Summary

• Symbol: Tg(Prnp*)8015Sbp
• Name: transgene insertion 8015, Stanley B Prusiner
• MGI ID: MGI:5314127
• Synonyms: PrP(deltaGPI), Tg8015
• Transgene: Tg(Prnp*)8015Sbp Location: unknown
• Alliance: Tg(Prnp*)8015Sbp page

Transgene origin

• Strain of Origin: FVB.129S7(B6)-Prnp^tm1Cwe/J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp*)8015Sbp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prnp (MGI:97769)

• Mutation details: A construct was designed by replacing the C-terminal glycosylphosphatidyl inositol (GPI) anchor signal with a myc tag and cloned into the cos.Tet vector. The cos.Tet vector is a cosmid-based expression vector derived from the Syrianhamster prion protein (Prnp) gene. Line 8015 was generated. (J:180145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This transgene was originally microinjected into Prnp^tm1Cwe oocytes.

References

• Original: J:180145 Stohr J, et al., Spontaneous generation of anchorless prions in transgenic mice. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21223-8
• All: 3 reference(s)