Mirc13 MGI Mouse Complex/Cluster/Region Detail - MGI:5313565 - microRNA cluster 13, including Mir141 through Mir200c

Mirc13 Complex/Cluster/Region Detail

Symbol

Mirc13
Name

microRNA cluster 13, including Mir141 through Mir200c

Feature Type

complex/cluster/region
IDs

MGI:5313565
Cluster Members

Mir141, Mir200c (2 members)

Sequence Map

Chr6:124694877-124695353 bp
From MGI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, Syntenic

SNPs within 2kb

34 from dbSNP Build 142

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Phenotype Summary

21 phenotypes from 2 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit partial protection from streptozotocin-induced diabetes and protection from high-fat diet induced disruption in glucose homeostasis and weight gain. Mice homozygous for a different null allele show decreased susceptibility to hepatic steatosis, liver injury and inflammation in response to a methionine- and choline-deficient (MCD) diet.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

8
Tissues

7
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

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All nucleic 1

Primer pair 1

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miRBase

MI0000166, MI0000694

Summaries

All 17

Developmental Gene Expression 1

Phenotypes 15
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:347005 Mostofa MG, et al., MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease. J Biol Chem. 2022 Apr 20;298(6):101966

Mirc13 Cluster contains:

More Data for these features

Member	Feature Type	Location
Mir141, microRNA 141	miRNA gene	Chr6:124694877-124694948 (-)
Mir200c, microRNA 200c	miRNA gene	Chr6:124695285-124695353 (-)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23