Tg(CTSG-NUMA1/RARA)#Skr
Transgene Detail

Summary

• Symbol: Tg(CTSG-NUMA1/RARA)#Skr
• Name: transgene insertion, Suzanne Kamel-Reid
• MGI ID: MGI:5307058
• Synonyms: hCG-NuMA-RARalpha TM
• Transgene: Tg(CTSG-NUMA1/RARA)#Skr Location: unknown
• Alliance: Tg(CTSG-NUMA1/RARA)#Skr page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CTSG-NUMA1/RARA)#Skr expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NUMA1 (4926)

  Numa1

  (MGI:2443665)

  human

  RARA (5914)

  Rara	(MGI:97856)

• Mutation details: This transgene consists of a fusion protein containing the N-terminal globular head domain and long central coiled-coil motif of NUMA1, including the oligomerization domain, and the C-terminus, domains C-F, of RARA, including the ATRA-binding site, RA-dependent DNA-binding site, and retinoid X receptor alpha and nuclear corepressor/coactivator interfaces, under the control of the human cathepsin G promoter. This fusion protein results from a translocation t(11:17)(q13;q21) associated with human cases of acute promyelocytic leukemia. The CTSG promoter drives expression in immature cells of the neutrophil lineage. RT-PCR indicates transgene expression in multiple organs at 4.5 months of age. Two lines were made but no line numbers were specified. (J:88103)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88103 Sukhai MA, et al., Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha. Oncogene. 2004 Jan 22;23(3):665-78
• All: 3 reference(s)