Tg(Lck-ETS2)1Boul
Transgene Detail

Summary

• Symbol: Tg(Lck-ETS2)1Boul
• Name: transgene insertion 1, Kim E Boulukos
• MGI ID: MGI:5306591
• Synonyms: lck-Ets2, lck^Pr-ets2
• Transgene: Tg(Lck-ETS2)1Boul Location: unknown
• Alliance: Tg(Lck-ETS2)1Boul page

Transgene origin

• Strain of Origin: C57BL/6 x DBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-ETS2)1Boul expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ETS2 (2114)

  Ets2	(MGI:95456)

• Mutation details: This transgene contains the full length, 2.1 kb human v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (ETS2) cDNA inserted into the p1017 expression vector between the T cell specific, proximal promoter from the mouse lymphocyte protein tyrosine kinase (Lck) gene and the human growth hormone (GH1) genomic sequence, including the GH1 polyadenylation signal. Based on Southern blot analysis, seven copies of the transgene are estimated to be present. Western blot analysis of total thymocyte lysates from these mice using anti-ETS2 antibodies demonstrates expression of the full-length ETS2 protein. (J:79809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:79809 Zaldumbide A, et al., The role of the ets2 transcription factor in the proliferation, maturation, and survival of mouse thymocytes. J Immunol. 2002 Nov 1;169(9):4873-81
• All: 1 reference(s)