Rnu2-8 MGI Mouse Gene Detail - MGI:5305946

Rnu2-8 Gene Detail

Symbol

Rnu2-8
Name

U2 small nuclear RNA 8
Synonyms

nmf291

Feature Type

snRNA gene
IDs

MGI:5305946
Alliance

gene page

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Sequence Map

Genome coordinates not available from the current reference assembly.

Genetic Map

Chromosome 11, Syntenic

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Chemically induced (other)

1
Find Mice (IMSR)

1 strains or lines available

Mice homozygous for a chemically-induced mutation develop tremors that progress to truncal ataxia and display an abnormal gait, a small cerebellum, and progressive hind limb weakness and cerebellar granule cell degeneration. Heterozygotes develop late onset tremors and granule cell degeneration.

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Summaries

All 3

Gene Ontology 1

Phenotypes 2
Earliest

J:179357 Jia Y, et al., Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration. Cell. 2012 Jan 20;148(1-2):296-308

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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