Tg(Mpz*Ala221fs)4Msch
Transgene Detail

Summary

• Symbol: Tg(Mpz*Ala221fs)4Msch
• Name: transgene insertion 4, Melitta Schachner
• MGI ID: MGI:5003323
• Synonyms: P0ins4, TgP0ins4, Tg(P0)ins4Msch
• Transgene: Tg(Mpz*Ala221fs)4Msch Location: unknown
• Alliance: Tg(Mpz*Ala221fs)4Msch page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mpz*Ala221fs)4Msch expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mpz (MGI:103177)

• Mutation details: The transgenic construct contains a mutant form of the mouse peripheral myelin protein zero (Mpz) gene in which a 97 bp fragment of a human MPZ cDNA, extending from the second nucleotide of exon 6 and encompassing the "P0ins" insertion associated with Dejerine-Sottas syndrome (DSS), has replaced the corresponding region of the mouse gene. The mutation comprises the insertion of CG between nucleotides 662 and 663, in exon 6, that causes a frameshift following amino acid 221 (Ala221fs). (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)