Tg(tetO-ABL1*P242E*P249E)CPdav
Transgene Detail

Summary

• Symbol: Tg(tetO-ABL1*P242E*P249E)CPdav
• Name: transgene insertion C, Peter Davies
• MGI ID: MGI:4940842
• Synonyms: AblPP, c-AblPP, TRE-AblPP, TRE-c-AblPP
• Transgene: Tg(tetO-ABL1*P242E*P249E)CPdav Location: unknown
• Alliance: Tg(tetO-ABL1*P242E*P249E)CPdav page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Constitutively active, Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-ABL1*P242E*P249E)CPdav expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ABL1 (25)

  Abl1	(MGI:87859)

• Tg(tetO-ABL1*P242E*P249E)CPdav expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	tetO

• Mutation details: The TRE-AblPP transgene was designed with a Tet response element (TRE) followed by a constitutively active c-Abl sequence (AblPP) and a beta-globin polyA sequence. The Tet response element (TRE) contains seven copies of the 42-bp tet operator sequence (tetO) just upstream of a minimal CMV promoter. To generate the AblPP sequence, a cDNA sequence encoding the nuclear-localizing isoform (1b) of the human c-Abl (ABL1; c-abl oncogene 1, non-receptor tyrosine kinase) was modified via site-directed mutagenesis to change the conserved proline residues of the SH2-SH3 linker region to glutamate (P242E/P249E). (J:169520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169520 Schlatterer SD, et al., Neuronal c-Abl Overexpression Leads to Neuronal Loss and Neuroinflammation in the Mouse Forebrain. J Alzheimers Dis. 2011 Mar 2;25(1):119-133
• All: 1 reference(s)