Tg(Tyr-Th,-Gch1)6775Lmon
Transgene Detail

Summary

• Symbol: Tg(Tyr-Th,-Gch1)6775Lmon
• Name: transgene insertion 6775, Lluis Montoliu
• MGI ID: MGI:4443311
• Synonyms: TyrTH
• Transgene: Tg(Tyr-Th,-Gch1)6775Lmon Location: unknown
• Alliance: Tg(Tyr-Th,-Gch1)6775Lmon page

Transgene origin

• Strain of Origin: NMRI

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tyr-Th,-Gch1)6775Lmon expresses 3 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  mouse

  Gch1 (MGI:95675)

  Transgene codes for a hybrid mouse and rat Th and a separate mouse Gch1.

  mouse

  Th (MGI:98735)

  Transgene codes for a hybrid mouse and rat Th and a separate mouse Gch1.

  rat

  Th (25085)

  Th	(MGI:98735)

  Transgene codes for a hybrid mouse and rat Th and a separate mouse Gch1.

• Mutation details: The mouse Tyr promoter was used to drive expression of a Th chimeric minigene composed of a mouse genomic fragment containing exons 1 and 2, rat cDNA containing sequence from exons 2 to 11, and mouse genomic sequence for exons 11 to 13. The Th minigene is deposited in GenBank as AY855842. An IRES element linked the Th construct to Gch1. Six founders were identified. Founder line 6775 contained four copies of the transgene and expressed the highest eye-specific tyrosine hydroxylase levels. (J:105984)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:105984 Lavado A, et al., Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin. J Neurochem. 2006 Feb;96(4):1201-11
• All: 1 reference(s)