Tg(Emu-BCL2L1)87Nnz
Transgene Detail

Summary

• Symbol: Tg(Emu-BCL2L1)87Nnz
• Name: transgene insertion 87, Gabriel Nunez
• MGI ID: MGI:4441458
• Synonyms: bcl-x-87
• Transgene: Tg(Emu-BCL2L1)87Nnz Location: unknown
• Alliance: Tg(Emu-BCL2L1)87Nnz page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Emu-BCL2L1)87Nnz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2L1 (598)

  Bcl2l1

  (MGI:88139)

• Mutation details: A human BCL2L1 cDNA was cloned under the regulatory control of the SV40 promoter and the IgH enhancer (Emu). The 2.4-kb fragment containing the SV40-Emu-bcl-xL insert was microinjected into F2 hybrid zygotes from (C57BL/6 x SJL/J)F l parents. Three founder mice expressing the human cDNA BCL2L1 in lymphoid tissue, as determined by Western blot analysis, were recovered. Expression was restricted to the B-cell compartment in Line 87. (J:31310)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:31310 Grillot DA, et al., bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med. 1996 Feb 1;183(2):381-91
• All: 10 reference(s)