Tg(SERPINA1-ENPP2)1Gbm
Transgene Detail

Summary

• Symbol: Tg(SERPINA1-ENPP2)1Gbm
• Name: transgene insertion 1, Gordon B Mills
• MGI ID: MGI:4437267
• Synonyms: Enpp2-Tg, Tg(A1AT-ENPP2), Tg(a1t1)ATX
• Transgene: Tg(SERPINA1-ENPP2)1Gbm Location: unknown
• Alliance: Tg(SERPINA1-ENPP2)1Gbm page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SERPINA1-ENPP2)1Gbm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ENPP2 (5168)

  Enpp2

  (MGI:1321390)

• Mutation details: The human SERPINA1 promoter drives expression a human ENPP2 cDNA. Immunoblot analysis detected increased protein levels in the lung. Hydrolysis of a fluorogeneic substrate (FS-3) is increased in the plasma. (J:148369, J:202085)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:148369 Pamuklar Z, et al., Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem. 2009 Mar 13;284(11):7385-94
• All: 7 reference(s)