Tg(Tcra3a.56,Tcrb3a.56)1Dorf
Transgene Detail

Summary

• Symbol: Tg(Tcra3a.56,Tcrb3a.56)1Dorf
• Name: transgene insertion 1, Martin E Dorf
• MGI ID: MGI:4415295
• Transgene: Tg(Tcra3a.56,Tcrb3a.56)1Dorf Location: unknown
• Alliance: Tg(Tcra3a.56,Tcrb3a.56)1Dorf page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra3a.56,Tcrb3a.56)1Dorf expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: This transgene expresses the re-arranged TCRalpha and TCRbeta chains derived from the encephalitogenic CD4⁺ TH1 cell clone 3a.56, which is specific for the 26-mer encoded by myelin basic protein (MBP) exon 2. (J:109724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Mice that express this transgene develop experimental autoimmune encephalomyelitis (EAE) upon immunization with myelin basic protein peptide.

References

• Original: J:155727 Abromson-Leeman S, et al., Encephalitogenic T cells that stably express both T-bet and ROR gamma t consistently produce IFNgamma but have a spectrum of IL-17 profiles. J Neuroimmunol. 2009 Oct 30;215(1-2):10-24
• All: 2 reference(s)