Tg(Gfap-cre)77.6Mvs
Transgene Detail
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Symbol: |
Tg(Gfap-cre)77.6Mvs |
Name: |
transgene insertion 77.6, Michael V Sofroniew |
MGI ID: |
MGI:3838840 |
Synonyms: |
mGFAP-Cre |
Transgene: |
Tg(Gfap-cre)77.6Mvs Location: unknown
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Alliance: |
Tg(Gfap-cre)77.6Mvs page
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Gfap-cre)77.6Mvs expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Gfap (MGI:95697) |
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Mutation details: The bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. Cre expression was detected in a small population of cells within the subependymal zone in the adult brain. No Cre expression or activity was detected during embryonic development or in the hippocampus.
(J:94543, J:146630)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Gfap
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:146630 Gregorian C, et al., Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J Neurosci. 2009 Feb 11;29(6):1874-86 |
All: |
100 reference(s) |
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