Xlch Gene Detail

Summary

• Symbol
  Xlch
• Name
  X-linked cardiac hypertrophy
• Synonyms
  Family 78, Hlb545

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:3797603
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome X, Syntenic

Human Diseases

• Diseases
  1 with Xlch mouse models

Human Disease

Mouse Models

X-linked dilated cardiomyopathy

IDs

X-linked dilated cardiomyopathy      

DOID:0110461
ICD10CM:I42.0
MESH:C580047
OMIM:302045

View 2 models

Mouse Models

Human Disease Modeled: X-linked dilated cardiomyopathy

Allelic Composition	Genetic Background	Reference	Phenotypes
Xlch/Xlch+	involves: C3H/HeJ * C57BL/6J	J:136798	View
Xlch/?	C57BL/6J-Xlch	J:136798	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 1 allele in 2 genetic backgrounds
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Chemically induced (ENU)
  1
• Find Mice (IMSR)
  0 strains or lines available

Heterozygotes for this ENU-induced mutation exhibit cardiac hypertrophy and partial lethality at birth.

References

• Summaries
  All 2

  Diseases 1

  Phenotypes 1
• Earliest
  J:136798 Leatherbury L, et al., A novel mouse model of X-linked cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2701-11