Tg(Myh6*)1Lnwd
Transgene Detail
|
Symbol: |
Tg(Myh6*)1Lnwd |
Name: |
transgene insertion 1, Leslie Leinwand |
MGI ID: |
MGI:3793766 |
Synonyms: |
deltaLCBDmyc |
Transgene: |
Tg(Myh6*)1Lnwd Location: unknown
|
Alliance: |
Tg(Myh6*)1Lnwd page
|
|
Strain of Origin: |
(C57BL/6 x FVB/N)F1
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Myh6*)1Lnwd expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
rat |
Myh6 (29556) |
|
|
|
|
|
Tg(Myh6*)1Lnwd expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
rat |
Myh6 (29556) |
|
|
|
|
|
Mutation details: Nucleotides 2,381 to 2,563 were deleted from published rat alpha-cardiac MHC and then fused to a COOH-terminal myc-tagged MHC fragment. This mutant cDNA was expressed under the control of a 3.3 kb of rat a-cardiac MHC promoter and the cDNA was followed by the mouse beta-globin terminator. The encoded protein lacks the light chain binding domain.
(J:55938)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:55938 Welikson RE, et al., Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice. Am J Physiol. 1999 Jun;276(6 Pt 2):H2148-58 |
All: |
2 reference(s) |
|