Tg(Ckm-LPL)1Rze
Transgene Detail

Summary

• Symbol: Tg(Ckm-LPL)1Rze
• Name: transgene insertion 1, Rudolf Zechner
• MGI ID: MGI:3789040
• Transgene: Tg(Ckm-LPL)1Rze Location: unknown
• Alliance: Tg(Ckm-LPL)1Rze page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-LPL)1Rze expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LPL (4023)

  Lpl	(MGI:96820)

• Mutation details: Mouse Ckm promoter was used to drive skeletal and cardiac muscle-specific expression of human LPL with a G to A transition at position 721 that results in an amino acid substitution of aspartic acid to asparagine at position 156 (D156N). This mutation results in an enzymatically inactive protein. Two lines were created (lines 1 and 2). (J:134517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134517 Merkel M, et al., Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13841-6
• All: 2 reference(s)