mgb Other Genome Feature Detail

Summary

• Symbol
  mgb
• Name
  megabladder

• Feature Type
  unclassified other genome feature
• IDs
  MGI:3772360

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 11, Syntenic

Human Diseases

• Diseases
  1 with mgb mouse models

Human Disease

Mouse Models

kidney disease

IDs

kidney disease      

DOID:557
EFO:0003086
ICD10CM:N08
ICD9CM:588.8
ICD9CM:588.89
MESH:D007674
NCI:C3149
UMLS_CUI:C0022658

View 1 model

Mouse Models

Human Disease Modeled: kidney disease

Allelic Composition	Genetic Background	Reference	Phenotypes
mgb/mgb	involves: C57BL/6 * FVB/N	J:207566	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  2 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  17 phenotypes from 1 allele in 2 genetic backgrounds
  4 phenotypes from multigenic genotypes
  15 phenotype references
  

• All Mutations and Alleles
  1
• Transgenic
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 15

  Diseases 2

  Phenotypes 15
• Earliest
  J:130545 Singh S, et al., Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction. J Am Soc Nephrol. 2007 Feb;18(2):461-71
• Latest
  J:283803 Houweling AC, et al., Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2;129(12):5374-5380